Endocrine Abstracts

Introduction: Hypothalamic AMP-activated protein kinase (AMPK) has emerged as a key molecular player in energy homeostasis. It participates of glucose homeostasis modulating liver glucose production. It is known that endotoxin shock presents various complicated metabolic aspects. Among them, in later phase circulatory collapse and hypoglycemia are induced with a deterioration of energy metabolism. Here we evaluated the participation of hypothalamic AMPK in the modulation of he...